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KMID : 0381920090390010017
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Korean Journal of Microscopy
2009 Volume.39 No. 1 p.17 ~ p.25
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Effects of Estrogen Receptor α-Selective Agonist Propyl Pyrazole Triol on the Morphology of Accessory Genital Glands of Male Mouse
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Han Ji-Yeon
Cho Hyun-Wook
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Abstract
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This study investigated that exposure of male mice to estrogen receptor α-selective agonist, 4,4′,4′′-(4-propyl-[1H] -pyrazole-1,3,5-triyl)tris-phenol (PPT) induce morphological changes of accessory genital glands. The male reproductive organs were fixed and processed for light microscopy. The PPT induced decreases of ventral prostates, seminal vesicles and preputial glands weights with experimental time. The glandular lumen of ventral prostate was atrophied compared with control group. Type of epithelial tissues in the prostate was changed from simple columnar epithelium to stratified cuboidal or squamous epithelium. Treated group with the agonist showed that increased connective tissue underlying epithelium in the prostate and seminal vesicle. Especially, the glandular lumen of the seminal vesicle was contracted when PPT-treated
animals were compared with control group. Secretion cells of preputial gland were smaller than that of control group. On week 8, PPT treatment caused decrease of epithelial cell height lining the lumen of preputial gland. These results provide
information useful in researching the physiological function of estrogen mediated by estrogen receptor α in male accessory genital gland.
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KEYWORD
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Estrogen receptor agonist, Male mouse, Accessory genital gland
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